Diabetes ± obesity et atherothrombosis/ stroke :
Predictive biomarkers of vascular complications
In comparison with in metropolitan France, Reunion is characterized by a high prevalence of the diabetes and the obesity (REDIA study) and an important mortality attributed to atherothrombosis. Paradoxicaly, the prevalence of dyslipidemia and the hypercholesterolemia in this atherogenous phenotype appear to be low. This paradox suggests a difference in lipoproteins function or a different mode of care in Reunion population.
On the methodological point of view, the epidemiological implementation of research tools which explore the causal link between the cardiometabolic risk factors and the clinical appearances of the atherothrombosis is facilitated by the “captive” character of the population. The great majority of the clinical events are supported financially by the health system of La Reunion.
Biological collections (plasma, DNA) associated with collection of clinical data will be constituted to allow case/ witness studies including stroke, acute coronary disease and apparently healthy control subjects groups. The cases will be taken in the acute phase of the stroke or the coronary infringement then included on the basis of the imaging (MRI / SCANNER) or the coronarography results.
These biological collections will allow to determine prevalence of dyslipidemia, to study the role of the phenotype of plasmatic lipoproteins (LDL oxidation and HDL functionality) and of some polymorphisms of various diabetes/obesity/insulinoresistance markers and the antidiabetics drugs.