Dr Jean-Loup Bascands

Diabète athérothrombose Thérapies Réunion Océan Indien  (UMR DéTROI  U1188) – Université de La Réunion-CYROI- 2, rue Maxime Rivière  97490 Sainte Clotilde – La Réunion – France
Tel : (262) 262 93 88 16 Fax : (262) 262 93 88 01

bascands-2-200x300PhD, Director of research

Contact:
jean-loup.bascands@inserm.fr

Road walked on:
Jean-Loup Bascands received his PhD from the University Paul Sabatier, Toulouse, France, in 1985. From 1983 up to now he worked as a scientist in the field of nephrology and was recruited as a research engineer at INSERM, in 1987. Between 2004 and 2016, Jean-Loup Bascands was a director of research at the Renal Fibrosis Lab, INSERM U1048. In 2016, he joined the new INSERM U1188 DéTROI group in Reunion Island.

Main domains of expertise:
Chronic kidney disease, Acute kidney disease, Animal experiments, Kinins, Renal fibrosis mechanisms

Selected Publications:
Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury. Belliere J, Casemayou A, Ducasse L, Zakaroff-Girard A, Martins F, Iacovoni JS, Guilbeau-Frugier C, Buffin-Meyer B, Pipy B, Chauveau D, Schanstra JP, Bascands JL. J Am Soc Nephrol. 2015 Jun;26(6):1363-77.

Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy. Lacroix C, Caubet C, Gonzalez-de-Peredo A, Breuil B, Bouyssié D, Stella A, Garrigues L, Le Gall C, Raevel A, Massoubre A, Klein J, Decramer S, Sabourdy F, Bandin F, Burlet-Schiltz O, Monsarrat B, Schanstra JP, Bascands JL. Mol Cell Proteomics. 2014 Dec;13(12):3421-34.

Blockade of the Kinin B1 Receptor Ameloriates Glomerulonephritis. Klein J, Gonzalez J, Decramer S, Bandin F, Neau E, Salant DJ, Heeringa P, Pesquero JB, Schanstra JP, Bascands JL. J Am Soc Nephrol. 2010 Jul;21(7):1157-64.

In vivo bradykinin B2 receptor activation reduces renal fibrosis. Schanstra JP, Neau E, Drogoz P, Arevalo Gomez MA, Lopez Novoa JM, Calise D, Pecher C, Bader M, Girolami JP, Bascands JL. J Clin Invest. 2002 Aug;110(3):371-9.

The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. Schanstra JP, Bataillé E, Marin Castaño ME, Barascud Y, Hirtz C, Pesquero JB, Pecher C, Gauthier F, Girolami JP, Bascands JL. J Clin Invest. 1998 May 15;101(10):2080-91.